hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06991
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KDM1A | Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) | UniProt NCBI |
| HMG20B | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35) | UniProt NCBI |
| PHF21A | PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) | UniProt NCBI |
| RCOR1 | REST corepressor 1 (Protein CoREST) | UniProt NCBI |
| HMG20A | High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1) | UniProt NCBI |
| RCOR3 | REST corepressor 3 | UniProt NCBI |
| BMP10 | Bone morphogenetic protein 10 (BMP-10) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:626 | 4.21681213412e-17 | 0.857142857143 | PHF21A RCOR3 HMG20A HMG20B KDM1A RCOR1 | LSD1 complex |
| CORUM:636 | 1.36207885204e-11 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | BHC complex |
| CORUM:620 | 3.17767167158e-11 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | CoREST-HDAC complex |
| CORUM:871 | 3.17767167158e-11 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | BRAF53-BRCA2 complex |
| CORUM:1492 | 1.90568103969e-10 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | BHC110 complex |
| CORUM:633 | 2.9941588088e-10 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | anti-BHC110 complex |
| CORUM:632 | 2.15733512906e-09 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | Anti-HDAC2 complex |
| CORUM:642 | 2.29297025836e-06 | 0.428571428571 | RCOR3 KDM1A RCOR1 | CtBP complex |
| REAC:R-HSA-3214815 | 8.21877381145e-06 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | HDACs deacetylate histones |
| CORUM:624 | 1.007158685e-05 | 0.285714285714 | KDM1A RCOR1 | LSD1-CoREST complex |
| CORUM:648 | 3.02079974644e-05 | 0.285714285714 | KDM1A RCOR1 | HDAC1-associated core complex cI |
| REAC:R-HSA-983231 | 7.13974352246e-05 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | Factors involved in megakaryocyte development and platelet production |
| CORUM:646 | 0.000362009370683 | 0.285714285714 | KDM1A RCOR1 | HDAC1-associated protein complex |
| CORUM:643 | 0.000362009370683 | 0.285714285714 | KDM1A RCOR1 | CtBP core complex |
| REAC:R-HSA-4839726 | 0.00058358382615 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | Chromatin organization |
| REAC:R-HSA-3247509 | 0.00058358382615 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | Chromatin modifying enzymes |
| REAC:R-HSA-109582 | 0.00890318946488 | 0.571428571429 | PHF21A HMG20B KDM1A RCOR1 | Hemostasis |
| HPA:013010_13 | 0.00934278012428 | 0.428571428571 | HMG20A KDM1A RCOR1 | endometrium 1; cells in endometrial stroma[Supported,High] |
| GO:1990391 | 0.0172381420268 | 0.428571428571 | PHF21A KDM1A RCOR1 | DNA repair complex |
| HPA:013010_03 | 0.0207760874908 | 0.428571428571 | HMG20A KDM1A RCOR1 | endometrium 1; cells in endometrial stroma[Uncertain,High] |
| HPA:004010_02 | 0.0253443002767 | 0.571428571429 | PHF21A HMG20A KDM1A RCOR1 | breast; adipocytes[Uncertain,Medium] |
| HPA:043020_13 | 0.0294137015062 | 0.428571428571 | HMG20A KDM1A RCOR1 | skin 1; fibroblasts[Supported,High] |
| HPA:021010_13 | 0.0392811660475 | 0.428571428571 | HMG20A KDM1A RCOR1 | heart muscle; myocytes[Supported,High] |
| CORUM:0000000 | 0.0437772681198 | 0.857142857143 | PHF21A RCOR3 HMG20A HMG20B KDM1A RCOR1 | CORUM root |
| HPA:027020_13 | 0.0463101748158 | 0.428571428571 | HMG20A KDM1A RCOR1 | lung; pneumocytes[Supported,High] |
| REAC:R-HSA-8943724 | 0.0499156916483 | 0.285714285714 | KDM1A RCOR1 | Regulation of PTEN gene transcription |
| CORUM:1233 | 0.0499886427319 | 0.142857142857 | RCOR1 | CoREST-HDAC2 complex |
| CORUM:2160 | 0.0499886427319 | 0.142857142857 | KDM1A | AOF2-AR complex |
| CORUM:6477 | 0.0499886427319 | 0.142857142857 | KDM1A | ZEB2-KDM1A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KDM1A | RCOR1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| PHF21A | HMG20B | 1.0 | 0.949 | hein_WMM bioplex (HMG20B) bioplex_WMM |
| HMG20A | HMG20B | 1.0 | 0.949 | hein_WMM bioplex (HMG20A,HMG20B) bioplex_WMM hein (HMG20A) |
| HMG20A | PHF21A | 0.999 | 0.949 | hein_WMM bioplex (HMG20A) bioplex_WMM boldt hein (HMG20A) boldt_WMM |
| KDM1A | RCOR3 | 0.997 | 0.93 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| RCOR1 | HMG20A | 0.996 | 0.926 | hein_WMM bioplex (HMG20A) bioplex_WMM boldt youn_WMM hein (HMG20A) boldt_WMM |
| KDM1A | HMG20A | 0.984 | 0.899 | hein_WMM bioplex (HMG20A) bioplex_WMM boldt youn_WMM hein (HMG20A) boldt_WMM |
| HMG20A | RCOR3 | 0.924 | 0.843 | hein_WMM bioplex (HMG20A) bioplex_WMM youn_WMM hein (HMG20A) |
| HMG20A | BMP10 | 0.778 | 0.752 | bioplex (HMG20A) bioplex_WMM |
| RCOR1 | HMG20B | 0.607 | 0.673 | hein_WMM bioplex (HMG20B) bioplex_WMM |
| KDM1A | HMG20B | 0.417 | 0.573 | hein_WMM bioplex (HMG20B) bioplex_WMM |
| RCOR3 | HMG20B | 0.4 | 0.56 | hein_WMM bioplex (HMG20B) bioplex_WMM |
| RCOR1 | RCOR3 | 0.089 | 0.356 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RCOR1 | PHF21A | 0.012 | 0.144 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RCOR3 | PHF21A | 0.012 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KDM1A | PHF21A | 0.011 | 0.145 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| BMP10 | HMG20B | 0.008 | 0.088 | bioplex_WMM WMM_only |
| BMP10 | PHF21A | 0.008 | 0.085 | bioplex_WMM WMM_only |
| RCOR1 | BMP10 | 0.008 | 0.023 | bioplex_WMM WMM_only |
| RCOR3 | BMP10 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| KDM1A | BMP10 | 0.008 | 0.025 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06991 has an average edge precision of 0.523 which is ranked 2379 out of all 6965 complexes.
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