hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06997

Confidence: Very High

Genename	Protein Name	Links
POLE3	DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)	UniProt NCBI
CHRAC1	Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15)	UniProt NCBI
POLE4	DNA polymerase epsilon subunit 4 (EC 2.7.7.7) (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0008622	9.08185760231e-07	1.0	CHRAC1 POLE3 POLE4	epsilon DNA polymerase complex
CORUM:234	2.01342304124e-05	0.666666666667	CHRAC1 POLE3	HuCHRAC complex
GO:0042575	5.08584025729e-05	1.0	CHRAC1 POLE3 POLE4	DNA polymerase complex
GO:0003887	0.000139860607076	1.0	CHRAC1 POLE3 POLE4	DNA-directed DNA polymerase activity
REAC:R-HSA-68952	0.000187420766709	0.666666666667	POLE4 POLE3	DNA replication initiation
REAC:R-HSA-174430	0.000187420766709	0.666666666667	POLE4 POLE3	Telomere C-strand synthesis initiation
KEGG:03410	0.000221829243661	0.666666666667	POLE4 POLE3	Base excision repair
KEGG:03030	0.000281708396768	0.666666666667	POLE4 POLE3	DNA replication
GO:0034061	0.000297521655052	1.0	CHRAC1 POLE3 POLE4	DNA polymerase activity
CORUM:6665	0.000305232445119	0.666666666667	POLE4 POLE3	ATAC complex, YEATS2-linked
CORUM:1108	0.000352175507891	0.666666666667	POLE4 POLE3	DNA synthesome complex (15 subunits)
KEGG:03420	0.000422858026176	0.666666666667	POLE4 POLE3	Nucleotide excision repair
CORUM:1111	0.000456110269427	0.666666666667	POLE4 POLE3	DNA synthesome complex (17 subunits)
CORUM:1099	0.000456110269427	0.666666666667	POLE4 POLE3	DNA synthesome complex (17 subunits)
REAC:R-HSA-5651801	0.00140483748394	0.666666666667	POLE4 POLE3	PCNA-Dependent Long Patch Base Excision Repair
REAC:R-HSA-174417	0.00184610965854	0.666666666667	POLE4 POLE3	Telomere C-strand (Lagging Strand) Synthesis
REAC:R-HSA-110373	0.00200655101382	0.666666666667	POLE4 POLE3	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
REAC:R-HSA-5696397	0.00200655101382	0.666666666667	POLE4 POLE3	Gap-filling DNA repair synthesis and ligation in GG-NER
REAC:R-HSA-110314	0.00290884705451	0.666666666667	POLE4 POLE3	Recognition of DNA damage by PCNA-containing replication complex
REAC:R-HSA-180786	0.00290884705451	0.666666666667	POLE4 POLE3	Extension of Telomeres
WP:WP4022	0.00294510433123	0.666666666667	POLE4 POLE3	Pyrimidine metabolism
REAC:R-HSA-5656169	0.00310931782116	0.666666666667	POLE4 POLE3	Termination of translesion DNA synthesis
REAC:R-HSA-68962	0.00353026371942	0.666666666667	POLE4 POLE3	Activation of the pre-replicative complex
REAC:R-HSA-73933	0.00397787610966	0.666666666667	POLE4 POLE3	Resolution of Abasic Sites (AP sites)
REAC:R-HSA-110313	0.0046992786316	0.666666666667	POLE4 POLE3	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
REAC:R-HSA-5696400	0.00548064029679	0.666666666667	POLE4 POLE3	Dual Incision in GG-NER
REAC:R-HSA-73893	0.00722314394396	0.666666666667	POLE4 POLE3	DNA Damage Bypass
REAC:R-HSA-6782210	0.0134604567412	0.666666666667	POLE4 POLE3	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-6782135	0.0138871493871	0.666666666667	POLE4 POLE3	Dual incision in TC-NER
REAC:R-HSA-5685942	0.0138871493871	0.666666666667	POLE4 POLE3	HDR through Homologous Recombination (HRR)
REAC:R-HSA-6781827	0.0200378707185	0.666666666667	POLE4 POLE3	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
GO:0016779	0.0201449224406	1.0	CHRAC1 POLE3 POLE4	nucleotidyltransferase activity
REAC:R-HSA-157579	0.0216163677069	0.666666666667	POLE4 POLE3	Telomere Maintenance
REAC:R-HSA-5696399	0.0232544758505	0.666666666667	POLE4 POLE3	Global Genome Nucleotide Excision Repair (GG-NER)
REAC:R-HSA-69002	0.0238137546255	0.666666666667	POLE4 POLE3	DNA Replication Pre-Initiation
REAC:R-HSA-73884	0.0249521708712	0.666666666667	POLE4 POLE3	Base Excision Repair
REAC:R-HSA-73886	0.0385024292001	0.666666666667	POLE4 POLE3	Chromosome Maintenance
REAC:R-HSA-5696398	0.0399448421955	0.666666666667	POLE4 POLE3	Nucleotide Excision Repair
REAC:R-HSA-69239	0.0459783176444	0.666666666667	POLE4 POLE3	Synthesis of DNA

Edges

Protein 1	Protein 2	Score	Precision	Evidence
POLE3	CHRAC1	0.988	0.901	bioplex_WMM Guru fraction
POLE3	POLE4	0.951	0.858	bioplex_WMM Guru Malo fraction

Images

Click to enlarge

Complex HuMAP2_06997 has an average edge precision of 0.879 which is ranked 669 out of all 6965 complexes.

Related Complexes

Genename	Complexes
POLE3	HuMAP2_00159 HuMAP2_00377 HuMAP2_02158 HuMAP2_03010 HuMAP2_04034 HuMAP2_05961 HuMAP2_06480 HuMAP2_06997
CHRAC1	HuMAP2_00377 HuMAP2_02158 HuMAP2_03010 HuMAP2_04034 HuMAP2_05961 HuMAP2_06997
POLE4	HuMAP2_00159 HuMAP2_00377 HuMAP2_05961 HuMAP2_06480 HuMAP2_06997

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_06997