hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_07002
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CHM | Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) | UniProt NCBI |
| RAB9A | Ras-related protein Rab-9A | UniProt NCBI |
| RAB31 | Ras-related protein Rab-31 (Ras-related protein Rab-22B) | UniProt NCBI |
| RAB22A | Ras-related protein Rab-22A (Rab-22) | UniProt NCBI |
| TRIM4 | E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4) | UniProt NCBI |
| GDI2 | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | UniProt NCBI |
| RAB9B | Ras-related protein Rab-9B (Rab-9-like protein) (Rab-9L) | UniProt NCBI |
| CHML | Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2) | UniProt NCBI |
| RABGGTA | Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) | UniProt NCBI |
| PCDHGB6 | Protocadherin gamma-B6 (PCDH-gamma-B6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8873719 | 3.79562522127e-13 | 0.7 | CHML CHM RABGGTA RAB9B RAB9A RAB22A RAB31 | RAB geranylgeranylation |
| REAC:R-HSA-8876198 | 1.2456820382e-09 | 0.6 | CHML CHM GDI2 RAB9B RAB9A RAB31 | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-9007101 | 8.39084241893e-09 | 0.6 | CHML CHM GDI2 RAB9B RAB9A RAB31 | Rab regulation of trafficking |
| GO:0005968 | 4.35775472874e-05 | 0.3 | CHML CHM RABGGTA | Rab-protein geranylgeranyltransferase complex |
| CORUM:6956 | 9.0534767973e-05 | 0.2 | CHM RABGGTA | REP-RGGT-Rab complex |
| REAC:R-HSA-199991 | 0.000131991736486 | 0.6 | CHML CHM GDI2 RAB9B RAB9A RAB31 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00018094052648 | 0.6 | CHML CHM GDI2 RAB9B RAB9A RAB31 | Vesicle-mediated transport |
| GO:0018344 | 0.000380900357231 | 0.3 | CHML CHM RABGGTA | protein geranylgeranylation |
| REAC:R-HSA-597592 | 0.000606384182679 | 0.7 | CHML CHM RABGGTA RAB9B RAB9A RAB22A RAB31 | Post-translational protein modification |
| GO:0018342 | 0.000913516286731 | 0.3 | CHML CHM RABGGTA | protein prenylation |
| GO:0097354 | 0.000913516286731 | 0.3 | CHML CHM RABGGTA | prenylation |
| GO:0019003 | 0.00299406076236 | 0.4 | RAB9A RAB9B RAB31 RAB22A | GDP binding |
| GO:0032482 | 0.00487122857055 | 0.4 | RAB9A RAB9B RAB31 RAB22A | Rab protein signal transduction |
| REAC:R-HSA-6803205 | 0.00659484253239 | 0.2 | CHM RABGGTA | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| REAC:R-HSA-392499 | 0.00692992953232 | 0.7 | CHML CHM RABGGTA RAB9B RAB9A RAB22A RAB31 | Metabolism of proteins |
| GO:0045335 | 0.00831412054194 | 0.4 | RAB9A RAB9B RAB31 RAB22A | phagocytic vesicle |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB31 | RAB22A | 1.0 | 0.949 | bioplex (RAB31) bioplex_WMM |
| CHML | RAB31 | 0.52 | 0.633 | bioplex (RAB31) bioplex_WMM |
| CHM | RAB31 | 0.401 | 0.561 | bioplex (RAB31) bioplex_WMM |
| RABGGTA | RAB31 | 0.275 | 0.487 | bioplex (RAB31) bioplex_WMM |
| RAB31 | TRIM4 | 0.193 | 0.446 | bioplex (RAB31) bioplex_WMM gupta_WMM |
| CHM | CHML | 0.099 | 0.358 | bioplex_WMM WMM_only boldt_WMM |
| CHML | RAB9A | 0.085 | 0.348 | bioplex (RAB9A) bioplex_WMM youn_WMM |
| RAB9A | GDI2 | 0.053 | 0.3 | bioplex (RAB9A) bioplex_WMM gupta_WMM |
| CHML | RABGGTA | 0.052 | 0.302 | bioplex (RABGGTA) bioplex_WMM |
| CHM | RAB9A | 0.043 | 0.268 | bioplex (RAB9A) bioplex_WMM |
| CHM | RABGGTA | 0.04 | 0.268 | bioplex (RABGGTA) bioplex_WMM |
| GDI2 | PCDHGB6 | 0.037 | 0.268 | fraction |
| CHM | GDI2 | 0.03 | 0.236 | hein_WMM bioplex_WMM youn_WMM WMM_only boldt_WMM |
| CHM | RAB9B | 0.029 | 0.23 | bioplex (RAB9B) bioplex_WMM |
| CHML | GDI2 | 0.028 | 0.231 | bioplex_WMM WMM_only boldt_WMM |
| RABGGTA | GDI2 | 0.017 | 0.173 | bioplex (RABGGTA) bioplex_WMM |
| RABGGTA | RAB9A | 0.014 | 0.138 | bioplex (RAB9A) bioplex_WMM |
| RAB31 | GDI2 | 0.013 | 0.141 | bioplex (RAB31) bioplex_WMM gupta_WMM |
| RAB22A | GDI2 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| RAB31 | RAB9A | 0.009 | 0.106 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| TRIM4 | RAB22A | 0.008 | 0.086 | bioplex_WMM WMM_only |
| CHML | RAB9B | 0.008 | 0.071 | bioplex (RAB9B) bioplex_WMM |
| RAB9A | RAB22A | 0.008 | 0.042 | bioplex_WMM WMM_only |
| CHML | RAB22A | 0.008 | 0.035 | bioplex_WMM WMM_only |
| RABGGTA | RAB22A | 0.008 | 0.04 | bioplex_WMM WMM_only |
| CHM | RAB22A | 0.008 | 0.041 | bioplex_WMM WMM_only |
| RABGGTA | RAB9B | 0.007 | 0.009 | bioplex (RAB9B) bioplex_WMM |
| TRIM4 | GDI2 | 0.007 | 0.008 | bioplex_WMM gupta_WMM WMM_only |
| CHML | TRIM4 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| RABGGTA | TRIM4 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| CHM | TRIM4 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| RAB9A | TRIM4 | 0.007 | 0.003 | youn_WMM gupta_WMM WMM_only |
| RAB9B | GDI2 | 0.007 | 0.003 | bioplex (RAB9B) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_07002 has an average edge precision of 0.209 which is ranked 6038 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CHM | HuMAP2_01067 HuMAP2_02250 HuMAP2_03796 HuMAP2_07002 |
| RAB9A | HuMAP2_01067 HuMAP2_03796 HuMAP2_07002 |
| RAB31 | HuMAP2_01067 HuMAP2_03796 HuMAP2_04471 HuMAP2_04752 HuMAP2_07002 |
| RAB22A | HuMAP2_03796 HuMAP2_04471 HuMAP2_04752 HuMAP2_07002 |
| TRIM4 | HuMAP2_02974 HuMAP2_03796 HuMAP2_07002 |
| GDI2 | HuMAP2_07002 |
| RAB9B | HuMAP2_03052 HuMAP2_07002 |
| CHML | HuMAP2_01067 HuMAP2_03796 HuMAP2_04752 HuMAP2_07002 |
| RABGGTA | HuMAP2_01067 HuMAP2_02113 HuMAP2_03796 HuMAP2_07002 |
| PCDHGB6 | HuMAP2_07002 |