hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_07006
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | UniProt NCBI |
| ACSL5 | Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5) | UniProt NCBI |
| HADH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | UniProt NCBI |
| NOVA2 | RNA-binding protein Nova-2 (Astrocytic NOVA1-like RNA-binding protein) (Neuro-oncological ventral antigen 2) | UniProt NCBI |
| PCBP3 | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | UniProt NCBI |
| NUDT19 | Nucleoside diphosphate-linked moiety X motif 19 (Nudix motif 19) (EC 3.6.1.-) | UniProt NCBI |
| HDAC10 | Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) | UniProt NCBI |
| NOVA1 | RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP357 | 0.00293552516575 | 0.25 | HADH ACSL5 | Fatty Acid Biosynthesis |
| WP:WP143 | 0.00710617802344 | 0.25 | HADH ACSL5 | Fatty Acid Beta Oxidation |
| WP:WP465 | 0.0088953208221 | 0.25 | HSD17B10 HADH | Tryptophan metabolism |
| REAC:R-HSA-8978868 | 0.0101629975921 | 0.375 | NUDT19 ACSL5 HADH | Fatty acid metabolism |
| KEGG:00071 | 0.0103387036304 | 0.25 | HADH ACSL5 | Fatty acid degradation |
| KEGG:00280 | 0.0129629809445 | 0.25 | HSD17B10 HADH | Valine, leucine and isoleucine degradation |
| KEGG:01212 | 0.0164978688692 | 0.25 | HADH ACSL5 | Fatty acid metabolism |
| KEGG:04146 | 0.0330272419157 | 0.25 | NUDT19 ACSL5 | Peroxisome |
| CORUM:7429 | 0.0497224828424 | 0.125 | HSD17B10 | HSD17B10-TRMT10C complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NOVA2 | NOVA1 | 1.0 | 0.949 | bioplex (NOVA1) bioplex_WMM youn_WMM |
| NOVA2 | HADH | 0.112 | 0.38 | fraction |
| HADH | NOVA1 | 0.109 | 0.376 | fraction |
| ACSL5 | HSD17B10 | 0.068 | 0.347 | fraction |
| ACSL5 | HADH | 0.066 | 0.347 | fraction |
| HADH | HSD17B10 | 0.061 | 0.339 | bioplex_WMM youn_WMM fraction treiber_WMM |
| NUDT19 | HSD17B10 | 0.035 | 0.261 | bioplex_WMM youn_WMM gupta_WMM fraction |
| HDAC10 | PCBP3 | 0.026 | 0.216 | bioplex (HDAC10) bioplex_WMM |
| NOVA1 | PCBP3 | 0.022 | 0.198 | fraction |
| NOVA2 | PCBP3 | 0.007 | 0.007 | fraction |
| HADH | NUDT19 | 0.007 | 0.002 | bioplex_WMM youn_WMM WMM_only |
| HDAC10 | HSD17B10 | 0.007 | 0.002 | bioplex (HDAC10) |
| NOVA2 | HSD17B10 | 0.004 | 0.009 | youn_WMM fraction |
| NOVA1 | HSD17B10 | 0.0 | 0.017 | youn_WMM fraction |
| PCBP3 | HSD17B10 | 0.0 | 0.011 | boldt gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_07006 has an average edge precision of 0.231 which is ranked 5688 out of all 6965 complexes.
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