hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04983
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NRXN3 | Neurexin-3-beta (Neurexin III-beta) [Cleaved into: Neurexin-3-beta, soluble form; Neurexin-3-beta, C-terminal fragment (NRXN3-CTF)] | UniProt NCBI |
| PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1-gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I gamma) (PIP5KIgamma) | UniProt NCBI |
| PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00562 | 0.00110943942397 | 0.666666666667 | PIP5K1C PIP5K1A | Inositol phosphate metabolism |
| KEGG:04666 | 0.0017077231529 | 0.666666666667 | PIP5K1C PIP5K1A | Fc gamma R-mediated phagocytosis |
| KEGG:05231 | 0.00174690264746 | 0.666666666667 | PIP5K1C PIP5K1A | Choline metabolism in cancer |
| KEGG:04070 | 0.00186709616111 | 0.666666666667 | PIP5K1C PIP5K1A | Phosphatidylinositol signaling system |
| KEGG:05135 | 0.00277005173367 | 0.666666666667 | PIP5K1C PIP5K1A | Yersinia infection |
| KEGG:04072 | 0.00350714576187 | 0.666666666667 | PIP5K1C PIP5K1A | Phospholipase D signaling pathway |
| WP:WP23 | 0.00365767654025 | 0.666666666667 | PIP5K1C PIP5K1A | B Cell Receptor Signaling Pathway |
| REAC:R-HSA-1660499 | 0.00753685558378 | 0.666666666667 | PIP5K1C PIP5K1A | Synthesis of PIPs at the plasma membrane |
| KEGG:04810 | 0.00772384569084 | 0.666666666667 | PIP5K1C PIP5K1A | Regulation of actin cytoskeleton |
| WP:WP51 | 0.0082449684177 | 0.666666666667 | PIP5K1C PIP5K1A | Regulation of Actin Cytoskeleton |
| KEGG:04144 | 0.0117748506163 | 0.666666666667 | PIP5K1C PIP5K1A | Endocytosis |
| REAC:R-HSA-6811558 | 0.015660289467 | 0.666666666667 | PIP5K1C PIP5K1A | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.0190186686906 | 0.666666666667 | PIP5K1C PIP5K1A | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-1483255 | 0.0200378707185 | 0.666666666667 | PIP5K1C PIP5K1A | PI Metabolism |
| GO:0016308 | 0.020283420769 | 0.666666666667 | PIP5K1C PIP5K1A | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIP5K1A | PIP5K1C | 0.992 | 0.912 | bioplex (PIP5K1A) bioplex_WMM |
| PIP5K1A | NRXN3 | 0.05 | 0.296 | bioplex (PIP5K1A) bioplex_WMM |
| PIP5K1C | NRXN3 | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04983 has an average edge precision of 0.43 which is ranked 3025 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NRXN3 | HuMAP2_04983 |
| PIP5K1C | HuMAP2_02132 HuMAP2_04983 HuMAP2_06505 |
| PIP5K1A | HuMAP2_02132 HuMAP2_04983 HuMAP2_06505 |