hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01790
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUZ12 | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | UniProt NCBI |
| NRBP2 | Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16) | UniProt NCBI |
| EPOP | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | UniProt NCBI |
| PHF1 | PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1) | UniProt NCBI |
| EZH2 | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | UniProt NCBI |
| PHF19 | PHD finger protein 19 (Polycomb-like protein 3) (hPCL3) | UniProt NCBI |
| EZH1 | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.43) (ENX-2) (Enhancer of zeste homolog 1) | UniProt NCBI |
| JARID2 | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | UniProt NCBI |
| AEBP2 | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | UniProt NCBI |
| EED | Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035098 | 5.76664197492e-23 | 0.9 | PHF19 JARID2 EZH2 PHF1 EPOP SUZ12 AEBP2 EED EZH1 | ESC/E(Z) complex |
| GO:0031519 | 5.54342188403e-18 | 0.9 | PHF19 JARID2 EZH2 PHF1 EPOP SUZ12 AEBP2 EED EZH1 | PcG protein complex |
| GO:0035097 | 1.16443089564e-15 | 0.9 | PHF19 JARID2 EZH2 PHF1 EPOP SUZ12 AEBP2 EED EZH1 | histone methyltransferase complex |
| WP:WP2916 | 6.9148408186e-15 | 0.6 | SUZ12 EZH2 EZH1 JARID2 AEBP2 EED | Interactome of polycomb repressive complex 2 (PRC2) |
| GO:0034708 | 1.79739278587e-14 | 0.9 | PHF19 JARID2 EZH2 PHF1 EPOP SUZ12 AEBP2 EED EZH1 | methyltransferase complex |
| REAC:R-HSA-212300 | 1.1349189148e-12 | 0.7 | PHF19 SUZ12 EZH2 PHF1 JARID2 AEBP2 EED | PRC2 methylates histones and DNA |
| GO:0045814 | 1.76262670846e-11 | 0.8 | PHF19 SUZ12 EZH2 PHF1 EED JARID2 AEBP2 EZH1 | negative regulation of gene expression, epigenetic |
| CORUM:7304 | 3.81057767206e-11 | 0.4 | EZH2 PHF19 EED SUZ12 | HIC1-PCL3L-PCR2 complex |
| CORUM:974 | 3.81057767206e-11 | 0.4 | EZH2 EED AEBP2 SUZ12 | EED-EZH2 complex |
| REAC:R-HSA-212165 | 1.84354547353e-10 | 0.7 | PHF19 SUZ12 EZH2 PHF1 JARID2 AEBP2 EED | Epigenetic regulation of gene expression |
| CORUM:6910 | 1.62176028613e-08 | 0.3 | EZH2 EED PHF19 | EED-EZH2-PHF19 complex |
| GO:0040029 | 4.43690504028e-08 | 0.8 | PHF19 SUZ12 EZH2 PHF1 EED JARID2 AEBP2 EZH1 | regulation of gene expression, epigenetic |
| CORUM:105 | 1.62061692851e-07 | 0.3 | EZH2 EED SUZ12 | Polycomb repressive complex 2 (PRC 2) |
| GO:0003682 | 1.69202530865e-07 | 0.8 | PHF19 JARID2 EZH2 PHF1 EPOP SUZ12 EED EZH1 | chromatin binding |
| GO:1990234 | 5.03786519234e-07 | 0.9 | PHF19 JARID2 EZH2 PHF1 EPOP SUZ12 AEBP2 EED EZH1 | transferase complex |
| HP:0001814 | 1.57833996515e-06 | 0.3 | EZH2 EED SUZ12 | Deep-set nails |
| WP:WP2369 | 4.51826231782e-06 | 0.4 | EZH2 EED EZH1 AEBP2 | Histone Modifications |
| GO:0044451 | 5.90355810369e-06 | 0.9 | PHF19 JARID2 EZH2 PHF1 EPOP SUZ12 AEBP2 EED EZH1 | nucleoplasm part |
| REAC:R-HSA-3214841 | 2.03817095002e-05 | 0.4 | EZH2 EED AEBP2 SUZ12 | PKMTs methylate histone lysines |
| CORUM:5521 | 3.01890677263e-05 | 0.2 | EZH2 EED | EED-EZH polycomb complex |
| HP:0010300 | 3.46378616618e-05 | 0.3 | EZH2 EED SUZ12 | Abnormally low-pitched voice |
| WP:WP4204 | 5.47158279761e-05 | 0.3 | EZH2 EED SUZ12 | Tumor suppressor activity of SMARCB1 |
| HP:0001816 | 5.726950151e-05 | 0.3 | EZH2 EED SUZ12 | Thin nail |
| GO:1902494 | 6.22011234658e-05 | 0.9 | PHF19 JARID2 EZH2 PHF1 EPOP SUZ12 AEBP2 EED EZH1 | catalytic complex |
| WP:WP4553 | 8.05314333416e-05 | 0.3 | EZH2 EED SUZ12 | FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma |
| CORUM:5502 | 9.0534767973e-05 | 0.2 | EZH2 EED | EED-EZH-YY1 polycomb complex |
| CORUM:1177 | 9.0534767973e-05 | 0.2 | EZH2 EED | Polycomb repressive complex 4 |
| CORUM:7375 | 9.0534767973e-05 | 0.2 | EZH2 SUZ12 | BRD7-EZH2-SUZ12 complex |
| GO:0046976 | 0.000108905457596 | 0.3 | EZH2 EED SUZ12 | histone methyltransferase activity (H3-K27 specific) |
| REAC:R-HSA-8953750 | 0.000269898234756 | 0.3 | EZH2 EED SUZ12 | Transcriptional Regulation by E2F6 |
| HP:0001176 | 0.000512885925627 | 0.3 | EZH2 EED SUZ12 | Large hands |
| HP:0001769 | 0.000571863230327 | 0.3 | EZH2 EED SUZ12 | Broad foot |
| REAC:R-HSA-74160 | 0.00070013120119 | 0.7 | PHF19 SUZ12 EZH2 PHF1 JARID2 AEBP2 EED | Gene expression (Transcription) |
| GO:0006325 | 0.000727184854317 | 0.7 | PHF19 EZH2 PHF1 EPOP JARID2 EED EZH1 | chromatin organization |
| HP:0002002 | 0.00121260238038 | 0.3 | EZH2 EED SUZ12 | Deep philtrum |
| REAC:R-HSA-8943724 | 0.00130904939949 | 0.3 | EZH2 EED SUZ12 | Regulation of PTEN gene transcription |
| GO:0070734 | 0.00179314168727 | 0.3 | EZH2 PHF1 PHF19 | histone H3-K27 methylation |
| HP:0001800 | 0.00206178499151 | 0.3 | EZH2 EED SUZ12 | Hypoplastic toenails |
| GO:0031491 | 0.00280486808764 | 0.4 | PHF19 EED PHF1 EZH1 | nucleosome binding |
| HP:0005616 | 0.00384779916014 | 0.3 | EZH2 EED SUZ12 | Accelerated skeletal maturation |
| WP:WP2853 | 0.00404291892122 | 0.3 | EZH2 AEBP2 JARID2 | Endoderm Differentiation |
| HP:0001582 | 0.00406835051437 | 0.3 | EZH2 EED SUZ12 | Redundant skin |
| GO:0034968 | 0.00408682796965 | 0.4 | EZH2 JARID2 PHF1 PHF19 | histone lysine methylation |
| REAC:R-HSA-3247509 | 0.0041964850839 | 0.4 | EZH2 EED AEBP2 SUZ12 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 0.0041964850839 | 0.4 | EZH2 EED AEBP2 SUZ12 | Chromatin organization |
| HP:0001852 | 0.00477987740585 | 0.3 | EZH2 EED SUZ12 | Sandal gap |
| HP:0011304 | 0.00503416384107 | 0.3 | EZH2 EED SUZ12 | Broad thumb |
| WP:WP4239 | 0.00520724077075 | 0.3 | EZH2 EED SUZ12 | Epithelial to mesenchymal transition in colorectal cancer |
| HP:0001609 | 0.00556927643388 | 0.3 | EZH2 EED SUZ12 | Hoarse voice |
| HP:0002213 | 0.00585039301888 | 0.3 | EZH2 EED SUZ12 | Fine hair |
| GO:0018022 | 0.00831412054194 | 0.4 | EZH2 JARID2 PHF1 PHF19 | peptidyl-lysine methylation |
| HP:0009768 | 0.00844385682417 | 0.3 | EZH2 EED SUZ12 | Broad phalanges of the hand |
| HP:0010624 | 0.00881326532308 | 0.3 | EZH2 EED SUZ12 | Aplastic/hypoplastic toenail |
| HP:0000311 | 0.00958380906364 | 0.3 | EZH2 EED SUZ12 | Round face |
| GO:0009892 | 0.00968048338812 | 0.9 | PHF19 NRBP2 JARID2 EZH2 PHF1 EED SUZ12 AEBP2 EZH1 | negative regulation of metabolic process |
| HP:0000973 | 0.00998522965779 | 0.3 | EZH2 EED SUZ12 | Cutis laxa |
| GO:0016571 | 0.0101052673197 | 0.4 | EZH2 JARID2 PHF1 PHF19 | histone methylation |
| REAC:R-HSA-5619507 | 0.0108219930226 | 0.3 | EZH2 EED SUZ12 | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.0108219930226 | 0.3 | EZH2 EED SUZ12 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| GO:0010629 | 0.0122395029652 | 0.8 | PHF19 SUZ12 EZH2 PHF1 EED JARID2 AEBP2 EZH1 | negative regulation of gene expression |
| REAC:R-HSA-2559580 | 0.0129085319269 | 0.3 | EZH2 EED SUZ12 | Oxidative Stress Induced Senescence |
| MIRNA:hsa-miR-138-5p | 0.0158293627622 | 0.3 | EZH2 EED SUZ12 | hsa-miR-138-5p |
| HP:0001500 | 0.0162521992163 | 0.3 | EZH2 EED SUZ12 | Broad finger |
| REAC:R-HSA-6807070 | 0.0174518822484 | 0.3 | EZH2 EED SUZ12 | PTEN Regulation |
| GO:0051276 | 0.0181227164942 | 0.7 | PHF19 EZH2 PHF1 EPOP JARID2 EED EZH1 | chromosome organization |
| HP:0006009 | 0.0198548415518 | 0.3 | EZH2 EED SUZ12 | Broad phalanx |
| HP:0001792 | 0.0205021463394 | 0.3 | EZH2 EED SUZ12 | Small nail |
| MIRNA:hsa-miR-101-3p | 0.0211355222921 | 0.4 | EZH2 EED AEBP2 SUZ12 | hsa-miR-101-3p |
| HP:0005622 | 0.0246797369582 | 0.3 | EZH2 EED SUZ12 | Broad long bones |
| HP:0008388 | 0.0302192006353 | 0.3 | EZH2 EED SUZ12 | Abnormal toenail morphology |
| HP:0008067 | 0.031939698511 | 0.3 | EZH2 EED SUZ12 | Abnormally lax or hyperextensible skin |
| HP:0000337 | 0.031939698511 | 0.3 | EZH2 EED SUZ12 | Broad forehead |
| GO:0006479 | 0.0341695302553 | 0.4 | EZH2 JARID2 PHF1 PHF19 | protein methylation |
| GO:0008213 | 0.0341695302553 | 0.4 | EZH2 JARID2 PHF1 PHF19 | protein alkylation |
| KEGG:00310 | 0.0349507932285 | 0.2 | EZH2 EZH1 | Lysine degradation |
| HP:0000098 | 0.0355714585811 | 0.3 | EZH2 EED SUZ12 | Tall stature |
| HP:0002164 | 0.0425614876374 | 0.3 | EZH2 EED SUZ12 | Nail dysplasia |
| GO:0031062 | 0.0438273782088 | 0.3 | PHF19 PHF1 JARID2 | positive regulation of histone methylation |
| REAC:R-HSA-2559583 | 0.0465488957083 | 0.3 | EZH2 EED SUZ12 | Cellular Senescence |
| HP:0002866 | 0.0499713747483 | 0.2 | EZH2 EED | Hypoplastic iliac wing |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SUZ12 | EZH2 | 1.0 | 0.949 | hein_WMM bioplex (SUZ12) bioplex_WMM hein (EZH2) Malo fraction |
| EZH2 | EED | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (EED,EZH2) Malo fraction |
| SUZ12 | EED | 0.999 | 0.949 | hein_WMM bioplex (SUZ12) bioplex_WMM youn_WMM hein (EED) |
| EZH2 | AEBP2 | 0.999 | 0.949 | hein_WMM bioplex (AEBP2) bioplex_WMM hein (EZH2) |
| AEBP2 | EED | 0.999 | 0.949 | hein_WMM bioplex (AEBP2) bioplex_WMM hein (EED) |
| SUZ12 | AEBP2 | 0.998 | 0.943 | hein_WMM bioplex (AEBP2,SUZ12) bioplex_WMM |
| SUZ12 | EPOP | 0.99 | 0.909 | hein_WMM bioplex (SUZ12) bioplex_WMM |
| SUZ12 | JARID2 | 0.899 | 0.824 | hein_WMM bioplex (SUZ12) bioplex_WMM fraction |
| 26148 | SUZ12 | 0.693 | 0.717 | hein_WMM bioplex (SUZ12) bioplex_WMM |
| JARID2 | AEBP2 | 0.626 | 0.678 | hein_WMM bioplex (AEBP2) bioplex_WMM |
| EED | PHF19 | 0.614 | 0.674 | hein_WMM bioplex (PHF19) bioplex_WMM hein (EED) |
| SUZ12 | EZH1 | 0.5 | 0.621 | bioplex (SUZ12) bioplex_WMM |
| SUZ12 | PHF1 | 0.404 | 0.563 | hein_WMM bioplex (SUZ12) bioplex_WMM |
| SUZ12 | PHF19 | 0.396 | 0.556 | hein_WMM bioplex (PHF19,SUZ12) bioplex_WMM |
| EZH2 | PHF19 | 0.347 | 0.536 | hein_WMM bioplex (PHF19) bioplex_WMM |
| EZH1 | PHF19 | 0.074 | 0.356 | bioplex (PHF19) bioplex_WMM |
| PHF19 | NRBP2 | 0.053 | 0.298 | bioplex (PHF19) bioplex_WMM |
| EPOP | EED | 0.012 | 0.146 | hein_WMM bioplex_WMM hein (EED) |
| EED | PHF1 | 0.012 | 0.148 | hein_WMM bioplex_WMM hein (EED) |
| 26148 | EZH2 | 0.012 | 0.145 | hein_WMM bioplex_WMM hein (EZH2) |
| EPOP | AEBP2 | 0.011 | 0.143 | hein_WMM bioplex_WMM WMM_only |
| EPOP | PHF1 | 0.011 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| AEBP2 | PHF1 | 0.01 | 0.126 | hein_WMM bioplex_WMM WMM_only |
| EPOP | JARID2 | 0.01 | 0.125 | hein_WMM bioplex_WMM WMM_only |
| EPOP | PHF19 | 0.01 | 0.104 | hein_WMM bioplex_WMM WMM_only |
| EZH2 | EZH1 | 0.01 | 0.104 | bioplex_WMM WMM_only |
| EED | EZH1 | 0.009 | 0.112 | bioplex_WMM WMM_only |
| 26148 | EPOP | 0.009 | 0.107 | hein_WMM bioplex_WMM WMM_only |
| JARID2 | PHF1 | 0.009 | 0.105 | hein_WMM bioplex_WMM WMM_only |
| AEBP2 | PHF19 | 0.009 | 0.109 | hein_WMM bioplex_WMM WMM_only |
| PHF19 | PHF1 | 0.009 | 0.101 | hein_WMM bioplex_WMM WMM_only |
| JARID2 | PHF19 | 0.009 | 0.09 | hein_WMM bioplex_WMM WMM_only |
| 26148 | AEBP2 | 0.009 | 0.096 | hein_WMM bioplex_WMM WMM_only |
| EPOP | EZH1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| 26148 | PHF19 | 0.008 | 0.088 | hein_WMM bioplex_WMM WMM_only |
| 26148 | PHF1 | 0.008 | 0.087 | hein_WMM bioplex_WMM WMM_only |
| 26148 | EZH1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| JARID2 | EZH1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| EZH1 | NRBP2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| EZH1 | PHF1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| AEBP2 | EZH1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| EZH2 | PHF1 | 0.008 | 0.059 | hein_WMM bioplex_WMM hein (EZH2) |
| 26148 | JARID2 | 0.008 | 0.033 | hein_WMM bioplex_WMM WMM_only |
| EZH2 | NRBP2 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| EED | NRBP2 | 0.008 | 0.022 | bioplex_WMM WMM_only |
| SUZ12 | NRBP2 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| EZH2 | EPOP | 0.007 | 0.006 | hein_WMM bioplex_WMM hein (EZH2) |
| JARID2 | EED | 0.007 | 0.004 | hein_WMM bioplex_WMM hein (EED) |
| EZH2 | JARID2 | 0.005 | 0.009 | hein_WMM bioplex_WMM hein (EZH2) |
| 26148 | EED | 0.005 | 0.013 | hein_WMM bioplex_WMM hein (26148,EED) |
Images
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Complex HuMAP2_01790 has an average edge precision of 0.303 which is ranked 4535 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUZ12 | HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578 |
| NRBP2 | HuMAP2_01790 HuMAP2_03308 HuMAP2_03960 |
| EPOP | HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 |
| PHF1 | HuMAP2_01790 HuMAP2_06150 HuMAP2_06914 |
| EZH2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578 |
| PHF19 | HuMAP2_01172 HuMAP2_01790 HuMAP2_03308 |
| EZH1 | HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03308 |
| JARID2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 |
| AEBP2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 |
| EED | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 |